Carman GM, et al. (2025) Insights into phosphatidic acid phosphatase and its potential role as a therapeutic target. Adv Biol Regul 95:101074 PMID:39788800
Stukey GJ, et al. (2025) The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases. J Lipid Res 66(1):100711 PMID:39577771
Han GS, et al. (2024) Catalytic core function of yeast Pah1 phosphatidate phosphatase reveals structural insight into its membrane localization and activity control. J Biol Chem 300(1):105560 PMID:38097185
Jog R, et al. (2024) The Saccharomyces cerevisiae Spo7 basic tail is required for Nem1-Spo7/Pah1 phosphatase cascade function in lipid synthesis. J Biol Chem 300(1):105587 PMID:38141768
Jog R, et al. (2024) The CTR hydrophobic residues of Nem1 catalytic subunit are required to form a protein phosphatase complex with Spo7 to activate yeast Pah1 PA phosphatase. J Biol Chem 300(12):108003 PMID:39551141
Jog R, et al. (2023) Conserved regions of the regulatory subunit Spo7 are required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid synthesis. J Biol Chem 299(5):104683 PMID:37030502
Stukey GJ, et al. (2023) Phosphatidate phosphatase Pah1 contains a novel RP domain that regulates its phosphorylation and function in yeast lipid synthesis. J Biol Chem 299(8):105025 PMID:37423305
Park Y, et al. (2022) Mutant phosphatidate phosphatase Pah1-W637A exhibits altered phosphorylation, membrane association, and enzyme function in yeast. J Biol Chem 298(2):101578 PMID:35026226
Pokharel M, et al. (2022) The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis. Microbiol Spectr 10(5):e0086222 PMID:36036637
Kwiatek JM and Carman GM (2020) Yeast phosphatidic acid phosphatase Pah1 hops and scoots along the membrane phospholipid bilayer. J Lipid Res 61(8):1232-1243 PMID:32540926
Mirheydari M, et al. (2020) The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism. J Biol Chem 295(33):11473-11485 PMID:32527729
Carman GM (2019) Discoveries of the phosphatidate phosphatase genes in yeast published in the Journal of Biological Chemistry. J Biol Chem 294(5):1681-1689 PMID:30061152
Carman GM and Han GS (2019) Fat-regulating phosphatidic acid phosphatase: a review of its roles and regulation in lipid homeostasis. J Lipid Res 60(1):2-6 PMID:30530634
Dey P, et al. (2019) Protein kinase C mediates the phosphorylation of the Nem1-Spo7 protein phosphatase complex in yeast. J Biol Chem 294(44):15997-16009 PMID:31501244
Hassaninasab A, et al. (2019) Yck1 casein kinase I regulates the activity and phosphorylation of Pah1 phosphatidate phosphatase from Saccharomyces cerevisiae. J Biol Chem 294(48):18256-18268 PMID:31645435
Konarzewska P, et al. (2019) Phosphatidylserine synthesis is essential for viability of the human fungal pathogen Cryptococcus neoformans. J Biol Chem 294(7):2329-2339 PMID:30602568
Su WM, et al. (2018) Protein kinase A phosphorylates the Nem1-Spo7 protein phosphatase complex that regulates the phosphorylation state of the phosphatidate phosphatase Pah1 in yeast. J Biol Chem 293(41):15801-15814 PMID:30201607
Dey P, et al. (2017) Phosphorylation of lipid metabolic enzymes by yeast protein kinase C requires phosphatidylserine and diacylglycerol. J Lipid Res 58(4):742-751 PMID:28154205
Hayes M, et al. (2017) Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes. Microb Cell 5(2):88-103 PMID:29417057
Park Y, et al. (2017) A conserved tryptophan within the WRDPLVDID domain of yeast Pah1 phosphatidate phosphatase is required for its in vivo function in lipid metabolism. J Biol Chem 292(48):19580-19589 PMID:29066621
Hsieh LS, et al. (2016) Phosphorylation of Yeast Pah1 Phosphatidate Phosphatase by Casein Kinase II Regulates Its Function in Lipid Metabolism. J Biol Chem 291(19):9974-90 PMID:27044741
Qiu Y, et al. (2016) Phosphorylation of Dgk1 Diacylglycerol Kinase by Casein Kinase II Regulates Phosphatidic Acid Production in Saccharomyces cerevisiae. J Biol Chem 291(51):26455-26467 PMID:27834677
Hsieh LS, et al. (2015) Phosphorylation regulates the ubiquitin-independent degradation of yeast Pah1 phosphatidate phosphatase by the 20S proteasome. J Biol Chem 290(18):11467-78 PMID:25809482
Park Y, et al. (2015) Altered Lipid Synthesis by Lack of Yeast Pah1 Phosphatidate Phosphatase Reduces Chronological Life Span. J Biol Chem 290(42):25382-94 PMID:26338708
Su WM, et al. (2014) Yeast Nem1-Spo7 protein phosphatase activity on Pah1 phosphatidate phosphatase is specific for the Pho85-Pho80 protein kinase phosphorylation sites. J Biol Chem 289(50):34699-708 PMID:25359770
Su WM, et al. (2014) Cross-talk phosphorylations by protein kinase C and Pho85p-Pho80p protein kinase regulate Pah1p phosphatidate phosphatase abundance in Saccharomyces cerevisiae. J Biol Chem 289(27):18818-30 PMID:24876385
Chae M and Carman GM (2013) Characterization of the yeast actin patch protein App1p phosphatidate phosphatase. J Biol Chem 288(9):6427-37 PMID:23335564
Karanasios E, et al. (2013) Regulation of lipid droplet and membrane biogenesis by the acidic tail of the phosphatidate phosphatase Pah1p. Mol Biol Cell 24(13):2124-33 PMID:23657815
Pascual F, et al. (2013) PAH1-encoded phosphatidate phosphatase plays a role in the growth phase- and inositol-mediated regulation of lipid synthesis in Saccharomyces cerevisiae. J Biol Chem 288(50):35781-92 PMID:24196957
Chae M, et al. (2012) The Saccharomyces cerevisiae actin patch protein App1p is a phosphatidate phosphatase enzyme. J Biol Chem 287(48):40186-96 PMID:23071111
Choi HS, et al. (2012) Pho85p-Pho80p phosphorylation of yeast Pah1p phosphatidate phosphatase regulates its activity, location, abundance, and function in lipid metabolism. J Biol Chem 287(14):11290-301 PMID:22334681
Soto-Cardalda A, et al. (2012) Phosphatidate phosphatase plays role in zinc-mediated regulation of phospholipid synthesis in yeast. J Biol Chem 287(2):968-77 PMID:22128164
Su WM, et al. (2012) Protein kinase A-mediated phosphorylation of Pah1p phosphatidate phosphatase functions in conjunction with the Pho85p-Pho80p and Cdc28p-cyclin B kinases to regulate lipid synthesis in yeast. J Biol Chem 287(40):33364-76 PMID:22865862
Choi HS, et al. (2011) Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependent kinase. J Biol Chem 286(2):1486-98 PMID:21081492
Fakas S, et al. (2011) Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast. J Biol Chem 286(33):29074-29085 PMID:21708942
Fakas S, et al. (2011) DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae. J Biol Chem 286(2):1464-74 PMID:21071438
Choi HS, et al. (2010) Phosphorylation of yeast phosphatidylserine synthase by protein kinase A: identification of Ser46 and Ser47 as major sites of phosphorylation. J Biol Chem 285(15):11526-36 PMID:20145252
Karanasios E, et al. (2010) A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase. Proc Natl Acad Sci U S A 107(41):17539-44 PMID:20876142
Chang YF and Carman GM (2008) CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae. Prog Lipid Res 47(5):333-9 PMID:18439916
Han GS, et al. (2008) An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth. J Biol Chem 283(29):20433-42 PMID:18458075
Soto A and Carman GM (2008) Regulation of the Saccharomyces cerevisiae CKI1-encoded choline kinase by zinc depletion. J Biol Chem 283(15):10079-88 PMID:18276583
Carman GM and Han GS (2007) Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion. Biochim Biophys Acta 1771(3):322-30 PMID:16807089
Carman GM and Henry SA (2007) Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae. J Biol Chem 282(52):37293-7 PMID:17981800
Chang YF, et al. (2007) Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation. J Biol Chem 282(24):17613-22 PMID:17463002
Choi MG and Carman GM (2007) Phosphorylation of human CTP synthetase 1 by protein kinase A: identification of Thr455 as a major site of phosphorylation. J Biol Chem 282(8):5367-77 PMID:17189248
Han GS, et al. (2007) The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity. J Biol Chem 282(51):37026-35 PMID:17971454
Han GS, et al. (2006) The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. J Biol Chem 281(14):9210-8 PMID:16467296
Kersting MC and Carman GM (2006) Regulation of the Saccharomyces cerevisiae EKI1-encoded ethanolamine kinase by zinc depletion. J Biol Chem 281(19):13110-13116 PMID:16551612
O'Hara L, et al. (2006) Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase. J Biol Chem 281(45):34537-48 PMID:16968695
Chang FS, et al. (2005) A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motility. J Cell Biol 171(1):133-42 PMID:16216926
Choi MG, et al. (2005) Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation. J Biol Chem 280(28):26105-12 PMID:15919656
Han GS, et al. (2005) Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. J Biol Chem 280(46):38328-36 PMID:16179339
Han SH, et al. (2005) Regulation of the PIS1-encoded phosphatidylinositol synthase in Saccharomyces cerevisiae by zinc. J Biol Chem 280(32):29017-24 PMID:15980062
Choi HS, et al. (2004) Regulation of phospholipid synthesis in the yeast cki1Delta eki1Delta mutant defective in the Kennedy pathway. The Cho1-encoded phosphatidylserine synthase is regulated by mRNA stability. J Biol Chem 279(13):12081-7 PMID:14739287
Han GS, et al. (2004) Vacuole membrane topography of the DPP1-encoded diacylglycerol pyrophosphate phosphatase catalytic site from Saccharomyces cerevisiae. J Biol Chem 279(7):5338-45 PMID:14630917
Choi MG, et al. (2003) Phosphorylation of Saccharomyces cerevisiae CTP synthetase at Ser424 by protein kinases A and C regulates phosphatidylcholine synthesis by the CDP-choline pathway. J Biol Chem 278(26):23610-6 PMID:12709422
Park TS, et al. (2003) Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae. J Biol Chem 278(23):20785-94 PMID:12670958
Sreenivas A and Carman GM (2003) Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase A. J Biol Chem 278(23):20673-80 PMID:12668681
Yu Y, et al. (2002) Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway. J Biol Chem 277(38):34978-86 PMID:12105205
Fernandez F, et al. (2001) The CWH8 gene encodes a dolichyl pyrophosphate phosphatase with a luminally oriented active site in the endoplasmic reticulum of Saccharomyces cerevisiae. J Biol Chem 276(44):41455-64 PMID:11504728
Han GS, et al. (2001) Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc. J Biol Chem 276(13):10126-33 PMID:11139591
Pierrugues O, et al. (2001) Lipid phosphate phosphatases in Arabidopsis. Regulation of the AtLPP1 gene in response to stress. J Biol Chem 276(23):20300-8 PMID:11278556
Sreenivas A, et al. (2001) Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase C. J Biol Chem 276(32):29915-23 PMID:11395523
Furneisen JM and Carman GM (2000) Enzymological properties of the LPP1-encoded lipid phosphatase from Saccharomyces cerevisiae. Biochim Biophys Acta 1484(1):71-82 PMID:10685032
Oshiro J, et al. (2000) Regulation of the DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol and growth phase. Inhibition of DGPP phosphatase activity by CDP-diacylglyceron and activation of phosphatidylserine synthase activity by DGPP. J Biol Chem 275(52):40887-96 PMID:11016943
Carman GM and Henry SA (1999) Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes. Prog Lipid Res 38(5-6):361-99 PMID:10793889
Faulkner A, et al. (1999) The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae. J Biol Chem 274(21):14831-7 PMID:10329682
Kent C and Carman GM (1999) Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus. Trends Biochem Sci 24(4):146-50 PMID:10322420
Kim K, et al. (1999) Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase. J Biol Chem 274(21):14857-66 PMID:10329685
Kim KH and Carman GM (1999) Phosphorylation and regulation of choline kinase from Saccharomyces cerevisiae by protein kinase A. J Biol Chem 274(14):9531-8 PMID:10092638
Pappas A, et al. (1999) Characterization of a novel dUTP-dependent activity of CTP synthetase from Saccharomyces cerevisiae. Biochemistry 38(50):16671-7 PMID:10600130
Park TS, et al. (1999) Identification of Ser424 as the protein kinase A phosphorylation site in CTP synthetase from Saccharomyces cerevisiae. Biochemistry 38(27):8839-48 PMID:10393561
Toke DA, et al. (1999) Mutagenesis of the phosphatase sequence motif in diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae. Biochemistry 38(44):14606-13 PMID:10545184
Kim KH, et al. (1998) Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae. J Biol Chem 273(12):6844-52 PMID:9506987
Ostrander DB, et al. (1998) Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae. J Biol Chem 273(30):18992-9001 PMID:9668079
Pappas A, et al. (1998) Nucleotide-dependent tetramerization of CTP synthetase from Saccharomyces cerevisiae. J Biol Chem 273(26):15954-60 PMID:9632643
Toke DA, et al. (1998) Isolation and characterization of the Saccharomyces cerevisiae DPP1 gene encoding diacylglycerol pyrophosphate phosphatase. J Biol Chem 273(6):3278-84 PMID:9452443
Toke DA, et al. (1998) Isolation and characterization of the Saccharomyces cerevisiae LPP1 gene encoding a Mg2+-independent phosphatidate phosphatase. J Biol Chem 273(23):14331-8 PMID:9603941
Carman GM and Zeimetz GM (1996) Regulation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. J Biol Chem 271(23):13293-6 PMID:8663192
Dillon DA, et al. (1996) The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity. J Biol Chem 271(48):30548-53 PMID:8940025
Wu WI, et al. (1996) Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae. J Biol Chem 271(4):1868-76 PMID:8567632
Yang WL and Carman GM (1996) Phosphorylation and regulation of CTP synthetase from Saccharomyces cerevisiae by protein kinase A. J Biol Chem 271(46):28777-83 PMID:8910520
Nadkarni AK, et al. (1995) Differential biochemical regulation of the URA7- and URA8-encoded CTP synthetases from Saccharomyces cerevisiae. J Biol Chem 270(42):24982-8 PMID:7559626
Ostrander DB, et al. (1995) Regulation of profilin localization in Saccharomyces cerevisiae by phosphoinositide metabolism. J Biol Chem 270(45):27045-50 PMID:7592954
Yang WL and Carman GM (1995) Phosphorylation of CTP synthetase from Saccharomyces cerevisiae by protein kinase C. J Biol Chem 270(25):14983-8 PMID:7797479
Nickels JT, et al. (1994) Regulation of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae by CDP-diacylglycerol. J Biol Chem 269(15):11018-24 PMID:8157627
Ozier-Kalogeropoulos O, et al. (1994) Use of synthetic lethal mutants to clone and characterize a novel CTP synthetase gene in Saccharomyces cerevisiae. Mol Gen Genet 242(4):431-9 PMID:8121398
Yang WL, et al. (1994) Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae. Biochemistry 33(35):10785-93 PMID:8075080
Buxeda RJ, et al. (1993) Regulation of the 45- and 55-kDa forms of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae by nucleotides. J Biol Chem 268(9):6248-55 PMID:8384205
Nickels JT and Carman GM (1993) Photoaffinity labeling of the 45-kDa and 55-kDa forms of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae. J Biol Chem 268(32):24083-8 PMID:8226954
Nickels JT, et al. (1992) Purification, characterization, and kinetic analysis of a 55-kDa form of phosphatidylinositol 4-kinase from Saccharomyces cerevisiae. J Biol Chem 267(23):16297-304 PMID:1322897
Quinlan JJ, et al. (1992) The 45- and 104-kDa forms of phosphatidate phosphatase from Saccharomyces cerevisiae are regulated differentially by phosphorylation via cAMP-dependent protein kinase. J Biol Chem 267(25):18013-20 PMID:1517235
Gaynor PM, et al. (1991) Regulation of phosphatidylethanolamine methyltransferase and phospholipid methyltransferase by phospholipid precursors in Saccharomyces cerevisiae. Biochim Biophys Acta 1090(3):326-32 PMID:1954254
Morlock KR, et al. (1991) Phosphatidate phosphatase from Saccharomyces cerevisiae. Isolation of 45- and 104-kDa forms of the enzyme that are differentially regulated by inositol. J Biol Chem 266(6):3586-93 PMID:1995619
Bae-Lee M and Carman GM (1990) Regulation of yeast phosphatidylserine synthase and phosphatidylinositol synthase activities by phospholipids in Triton X-100/phospholipid mixed micelles. J Biol Chem 265(13):7221-6 PMID:2158994
Kinney AJ and Carman GM (1990) Enzymes of phosphoinositide synthesis in secretory vesicles destined for the plasma membrane in Saccharomyces cerevisiae. J Bacteriol 172(7):4115-7 PMID:2163397
Kinney AJ, et al. (1990) Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by cyclic AMP-dependent protein kinase. J Bacteriol 172(2):1133-6 PMID:2153654
Lin YP and Carman GM (1989) Purification and characterization of phosphatidate phosphatase from Saccharomyces cerevisiae. J Biol Chem 264(15):8641-5 PMID:2542283
Belunis CJ, et al. (1988) Purification and characterization of phosphatidylinositol kinase from Saccharomyces cerevisiae. J Biol Chem 263(35):18897-903 PMID:2848810
Kelley MJ, et al. (1988) Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by inositol. Inositol is an inhibitor of phosphatidylserine synthase activity. J Biol Chem 263(34):18078-85 PMID:2848023
Kinney AJ and Carman GM (1988) Phosphorylation of yeast phosphatidylserine synthase in vivo and in vitro by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A 85(21):7962-6 PMID:2847149
Klig LS, et al. (1988) Saccharomyces cerevisiae mutant with a partial defect in the synthesis of CDP-diacylglycerol and altered regulation of phospholipid biosynthesis. J Bacteriol 170(4):1878-86 PMID:2832385
Bailis AM, et al. (1987) The membrane-associated enzyme phosphatidylserine synthase is regulated at the level of mRNA abundance. Mol Cell Biol 7(1):167-76 PMID:3031455
Homann MJ, et al. (1987) Coordinate regulation of phospholipid biosynthesis by serine in Saccharomyces cerevisiae. J Bacteriol 169(7):3276-80 PMID:3036783
Kelley MJ and Carman GM (1987) Purification and characterization of CDP-diacylglycerol synthase from Saccharomyces cerevisiae. J Biol Chem 262(30):14563-70 PMID:2822695
Fernandez S, et al. (1986) Metabolism of the phospholipid precursor inositol and its relationship to growth and viability in the natural auxotroph Schizosaccharomyces pombe. J Bacteriol 166(3):779-86 PMID:3011744
Poole MA, et al. (1986) Regulation of phosphatidylserine synthase from Saccharomyces cerevisiae by phospholipid precursors. J Bacteriol 168(2):668-72 PMID:3023284
Bae-Lee MS and Carman GM (1984) Phosphatidylserine synthesis in Saccharomyces cerevisiae. Purification and characterization of membrane-associated phosphatidylserine synthase. J Biol Chem 259(17):10857-62 PMID:6088519
Letts VA, et al. (1983) Isolation of the yeast structural gene for the membrane-associated enzyme phosphatidylserine synthase. Proc Natl Acad Sci U S A 80(23):7279-83 PMID:6316353
Carman GM and Matas J (1981) Solubilization of microsomal-associated phosphatidylserine synthase and phosphatidylinositol synthase from Saccharomyces cerevisiae. Can J Microbiol 27(11):1140-9 PMID:6274497