Tardiff DF, et al. (2024) A Genome-Wide Analysis Indicates that Yeast Pre-mRNA Splicing Is Predominantly Posttranscriptional. Mol Cell 84(16):3165 PMID:39116873
Piotrowski JS and Tardiff DF (2019) From Yeast to Humans: Leveraging New Approaches in Yeast to Accelerate Discovery of Therapeutic Targets for Synucleinopathies. Methods Mol Biol 2049:419-444 PMID:31602625
Khurana V, et al. (2017) Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. Cell Syst 4(2):157-170.e14 PMID:28131822
Tardiff DF, et al. (2017) Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. ACS Chem Neurosci 8(9):2039-2055 PMID:28628299
Matlack KE, et al. (2014) Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci U S A 111(11):4013-8 PMID:24591589
Tardiff DF, et al. (2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342(6161):979-83 PMID:24158909
Su LJ, et al. (2010) Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech 3(3-4):194-208 PMID:20038714
Tardiff DF, et al. (2007) Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking. Proc Natl Acad Sci U S A 104(50):19948-53 PMID:18077427
Lacadie SA, et al. (2006) In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants. Genes Dev 20(15):2055-66 PMID:16882983
Tardiff DF and Rosbash M (2006) Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly. RNA 12(6):968-79 PMID:16618970
Tardiff DF, et al. (2006) A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional. Mol Cell 24(6):917-29 PMID:17189193
Du H, et al. (2004) Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation. Proc Natl Acad Sci U S A 101(41):14841-6 PMID:15465910