Complex: NatA N-alpha-acetyltransferase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-783
- Systematic Name
- ARD1:NAT1:NAT5
- SGD ID
- SGD:S000217909
- Aliases
- N(alpha)-acetyltransferase NatA ; N-terminal acetyltransferase A complex ; NatA Nalpha-terminal acetyltransferase ; NatE complex
- Description
- N(alpha)-acetyltransferases, NatA, NatB (CPX-782) and NatC (CPX-781), carry out N-terminal acetylation, one of the most common co-translational modifications. NatA is the major Nalpha-terminal acetyltransferase in the yeast cytosol, responsible for the acetylation of serine, alanine, threonine, and glycine. NAT1 anchors to the ribosome and interacts with nascent polypeptides.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables protein-N-terminal amino-acid acetyltransferase activity (IDA)
- Biological Process
-
- involved in N-terminal protein amino acid acetylation (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Deng S, et al. (2019) Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex. Structure 27(7):1057-1070.e4 PMID: 31155310
- Perrot M, et al. (2008) Sequence requirements for Nalpha-terminal acetylation of yeast proteins by NatA. Yeast 25(7):513-27 PMID: 18615858
- Polevoda B and Sherman F (2003) Composition and function of the eukaryotic N-terminal acetyltransferase subunits. Biochem Biophys Res Commun 308(1):1-11 PMID: 12890471
- Polevoda B and Sherman F (2001) NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. J Biol Chem 276(23):20154-9 PMID: 11274203
Resources
IntAct | ModelArchive | PDB:6HD5 | PDB:6O07 ... Show all Show fewer