the formation of a pre-initiation complex (pic) is the first step that takes place during transcription by rNa polymerase ii (pol ii). the tata-binding protein binds to the tata box, thereby positioning the polymerase in the pic in such a way that it can unwind downstream DNa and lock the template strand in the active site (Bushnell et al, 2004). in metazoans, initiation takes place 25?30 base pairs (bp) downstream of the tata box (Smale & Kadonaga, 2003), whereas in Saccharomyces cerevisiae, start sites are spread across 40?120 bp downstream of the tata box (Hampsey, 1998). the rules that control selection of the pol ii start point are not well understood. in metazoans, start sites often occur at a conserved initiator sequence (Smale & Kadonaga, 2003), whereas yeast initiators are more divergent (zhang & Dietrich, 2005) and the polymerase has been proposed to ?scan? the downstream sequences for optimal start sites (giardina & Lis, 1993; Kuehner & Brow, 2008). Several articles recently published by the Brow, Lacroute, Libri and reines laboratories show that start-site selection has an important role in regulating the expression of genes of the S. cerevisiae nucleotide-biosynthetic pathways (Jenks et al, 2008; Kuehner & Brow, 2008; Kwapisz et al, 2008; thiebaut et al, 2008).
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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