[Amiodarone is used as a pharmaceutical substance for treating a number of diseases. However it is known that structural and functional disturbances are caused by amiodarone in patient's tissues. Here particular features of amiodarone effect are studied in yeast Saccharomyces cerevisiae, where amiodarone was shown to cause apoptosis. Electron-microscopic study of yeast cells after amiodarone treatment reveals a significant increase in lipid particle number which can lead to formation of a structural complex by interacting with membranous organelles of a cell. Amiodarone causes the appearance of small and separated slightly swollen mitochondria. Chro-matin displacement to the periphery of nucleus, nuclear sectioning and nuclear envelope disturbances are observed in the cells under these conditions. The detected cell ultrastructure alterations in the S. cerevisiae are considered to be specific response to the phospholipidosis and apoptosis caused by amiodarone.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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