Graph clustering becomes difficult as the graph size and complexity increase. In particular, in interaction graphs, the clusters are small and the data on the underlying interaction are not only complex, but also noisy due to the lack of information and experimental errors. The graphs representing such data consist of (possibly overlapping) clusters of non-uniform size with some false positive and false negative links. In this article, we propose a new approach, assuming that clusters in the graphs of protein-protein interaction (PPI) networks resemble corrupted cliques. Therefore, the problem can be reduced to looking for clusters only among nodes of approximately similar degrees. This idea was implemented using a soft version of the Farthest-Point-First (FPF) clustering algorithm with the Jaccard distance function modified to perform on slightly overlapping clusters. The StripClust program developed by us was tested on a synthetic network and on the yeast PPI network.
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Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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Site | Modification | Modifier | Source | Reference |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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