Reference: Ferrero I, et al. (1984) ALG/alg: a single gene controlling the utilization of lactate in the presence of antimycin in the yeast Saccharomyces cerevisiae. Curr Genet 8(6):407-11

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Abstract


A strain dependent growth on lactate in the presence of antimycin A (AA) has been observed - the strain D261 can grow on lactate and AA, whereas in the strain K8/6C antimycin A prevents the utilization of lactate and the induction of LDH.Genetic analysis demonstrates that growth on lactate in the presence of AA segregates from D261 as a single nuclear factor which we indicate by ALG1 and alg1 in its dominant and recessive states. alg1 complements the gene(s) which give(s) rise to the same phenotype in K8/6C.The analysis of the regulation by lactate of LDH in the absence and presence of AA and in rho (-) cells shows that growth on lactate and antimycin A is not corretated with the induction by lactate of LDH.

Reference Type
Journal Article
Authors
Ferrero I, Rambaldelli R, Genga AM, Donnini C, Puglisi PP
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