In this study, we developed terahertz (THz) metamaterial devices with attenuated total reflection (ATR) geometries for biosensing applications. This was achieved by transferring the metamaterial patterns fabricated on a polyimide film to a prism-top surface. We characterized the resonance characteristics of metasurfaces for different THz wave polarizations and gap structure orientations in the metamaterials. The metamaterial resonances exhibited a sharp resonance compared to the normal incidence case; the quality factor increased from 3.3 to 6.0. For biosensing applications, we measured the resonant-frequency shift of the hybrid device by depositing yeast cells. The sensitivity in terms of the yeast number density increased 3.4 times compared to that of the Si substrate under normal incidence, which presented a 4.1-fold increase in the figure of merit. The resonance characteristics based on finite-difference time-domain simulations successfully reproduced our experimental results, including the enhanced sensitivity of our hybrid devices.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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