AboutBlogDownloadExploreHelpGet Data

Allele: iqg1-4A

Allele Name
iqg1-4A 1
SGD ID
SGD:S000277299
Affected Gene
IQG1
Allele Type
missense variant 1
Description
all four perfect consensus Cdk sites mutated to alanine to prevent phosphorylation

Phenotype Annotations

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

3 entries for 3 phenotypes

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

GenePhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
IQG1actin cytoskeleton morphology: abnormal
classical geneticsactivation
Allele: iqg1-4A

S7A, T299A, S354A, S404A; Cdk consensus phosphorylation sites mutated; constitutively active

W303Treatment: alpha-factor block release
Details: premature formation of the actin ring, prior to anaphase
Miller DP, et al. (2015) PMID:26085509
IQG1bud neck morphology: abnormal
classical geneticsactivation
Allele: iqg1-4A

S7A, T299A, S354A, S404A; Cdk consensus phosphorylation sites mutated; constitutively active

W303Details: bud necks are larger than wild-type controls increasing in size from 1.3 to 1.9 micrometers
Miller DP, et al. (2015) PMID:26085509
IQG1cytokinesis: decreased
classical geneticsactivation
Allele: iqg1-4A

S7A, T299A, S354A, S404A; Cdk consensus phosphorylation sites mutated; constitutively active

W303Details: increased frequency (32%) of chain formation relative to wt (9.5%) in zymolyase treated cells
Miller DP, et al. (2015) PMID:26085509
Showing 1 to 3 of 3 entries

References

List of references used specifically to curate the information in Overview section.

  1. Miller DP, et al. (2015) Dephosphorylation of Iqg1 by Cdc14 regulates cytokinesis in budding yeast. Mol Biol Cell 26(16):2913-26 PMID: 26085509

Resources

Mutant Strains

Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC

Phenotype Resources

dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome

Ontology

Yeast Phenotype Ontology

Interactions Resources

BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap | YeastRC Two-Hybrid