Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
18 entries for 10 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| MPP6 | chronological lifespan: decreased | systematic mutation set | null Allele: mpp6-Δ | S288C | Marek A and Korona R (2013) PMID:24151994 | ||
| MPP6 | competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: mpp6-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.984 | Breslow DK, et al. (2008) PMID:18622397 | |
| MPP6 | competitive fitness: decreased | systematic mutation set | null Allele: mpp6-Δ | S288C | Media: rich medium (YPD) w/6% ethanol, ETH | Qian W, et al. (2012) PMID:23103169 | |
| MPP6 | competitive fitness: decreased | systematic mutation set | null Allele: mpp6-Δ | S288C | Media: synthetic complete medium, SC | Qian W, et al. (2012) PMID:23103169 | |
| MPP6 | competitive fitness: decreased | systematic mutation set | null Allele: mpp6-Δ | S288C | Media: YPD | Qian W, et al. (2012) PMID:23103169 | |
| MPP6 | innate thermotolerance: increased | homozygous diploid, systematic mutation set | null Allele: mpp6-Δ | S288C | Phase: stationary phase Treatment: heat shock, 50 °C Details: resistance scale of 1 (least) to 4 (most) resistant: 2 | Jarolim S, et al. (2013) PMID:24142923 | |
| MPP6 | resistance to chemicals: decreased | homozygous diploid, systematic mutation set | null Allele: mpp6-Δ | S288C | benzo[a]pyrene | O'Connor ST, et al. (2012) PMID:23403841 | |
| MPP6 | resistance to chemicals: decreased | classical genetics | null Allele: mpp6-Δ | W303 | 6 mM caffeine | Temperature: permissive temperature, 30 °C Details: hypersensitive; growth significantly restored by addition of 1M sorbitol | Novačić A, et al. (2021) PMID:33439673 |
| MPP6 | resistance to chemicals: increased | classical genetics | null Allele: mpp6-Δ | S288C | sirolimus | Details: moderate resistance; sirolimus is rapamycin | Huber A, et al. (2009) PMID:19684113 |
| MPP6 | resistance to chemicals: increased | systematic mutation set | null Allele: mpp6-Δ | S288C | 500 uM tirapazamine | Hellauer K, et al. (2005) PMID:16061773 |
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
68 entries for 62 genesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Interactor | Interactor | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | BRX1 | mpp6-Δ, brx1-5001 | Negative Genetic | high-throughput | Bait-Hit | -0.1381 | 0.02033 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | CAT5 | mpp6-Δ, cat5-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.286 | 0.001713 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | CLP1 | mpp6-Δ, clp1-5001 | Negative Genetic | high-throughput | Bait-Hit | -0.2155 | 0.002587 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | COQ10 | mpp6-Δ, coq10-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1776 | 0.01864 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | FAA1 | mpp6-Δ, faa1-Δ | Positive Genetic | high-throughput | Bait-Hit | 0.1726 | 0.006293 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | HMI1 | mpp6-Δ, hmi1-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1217 | 0.01089 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | IPL1 | mpp6-Δ, ipl1-2 | Negative Genetic | high-throughput | Bait-Hit | -0.1319 | 0.01989 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | MCH4 | mpp6-Δ, mch4-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1759 | 6.316E-15 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | MPP6 | MDM32 | mdm32-Δ, mpp6-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1982 | 0.003353 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | BCD1 | MPP6 | bcd1-5001, mpp6-Δ | Positive Genetic | high-throughput | Bait-Hit | 0.1859 | 6.939E-42 | Costanzo M, et al. (2016) PMID:27708008 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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