Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
34 entries for 23 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| RDH54 | chromosome/plasmid maintenance: abnormal | classical genetics | null Allele: rdh54-Δ | S288C | Assay: a-like faker (ALF) assay Details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype | Yuen KW, et al. (2007) PMID:17360454 | |
| RDH54 | chromosome/plasmid maintenance: abnormal | homozygous diploid | null Allele: rdh54-Δ | S288C | Assay: diploid bimater (BiM) assay Details: indicative of chromosome instability (CIN); high confidence set; 3-fold increase over wildtype | Yuen KW, et al. (2007) PMID:17360454 | |
| RDH54 | chromosome/plasmid maintenance: decreased | classical genetics | null Allele: rdh54-Δ | S288C | Details: small, 3-fold increase in the rate of gross chromosomal rearrangement (GCR), indicative of genome instability | Myung K, et al. (2001) PMID:11429610 | |
| RDH54 | colony sectoring: increased | classical genetics | null Allele: rdh54-Δ | S288C | Assay: chromosome transmission fidelity (CTF) assay Details: indicative of chromosome instability (CIN); high confidence set; mild sectoring phenotype | Yuen KW, et al. (2007) PMID:17360454 | |
| RDH54 | competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: rdh54-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.96 | Breslow DK, et al. (2008) PMID:18622397 | |
| RDH54 | desiccation resistance: decreased | systematic mutation set | null Allele: rdh54-Δ | S288C | Details: less than 10% viability after dehydration stress | Rodríguez-Porrata B, et al. (2012) PMID:22181064 | |
| RDH54 | gamma ray resistance: decreased | homozygous diploid, competitive growth | null Allele: rdh54-Δ | S288C | Game JC, et al. (2003) PMID:12816519 | ||
| RDH54 | haploproficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: rdh54-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: 0.0034 | Pir P, et al. (2012) PMID:22244311 | |
| RDH54 | innate thermotolerance: increased | homozygous diploid, systematic mutation set | null Allele: rdh54-Δ | S288C | Phase: stationary phase Treatment: heat shock, 50 °C Details: resistance scale of 1 (least) to 4 (most) resistant: 2 | Jarolim S, et al. (2013) PMID:24142923 | |
| RDH54 | lifespan: increased | systematic mutation set | null Allele: rdh54-Δ | S288C | Media: cells stored on YPD plates at 4 deg C for 5 years Details: hibernating lifespan extended | Postma L, et al. (2009) PMID:20157578 |
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
40 entries for 41 genesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Interactor | Interactor | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | ARE2 | are2-Δ, rdh54-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1614 | 0.000006251 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | ARP3 | arp3-31, rdh54-Δ | Positive Genetic | high-throughput | Hit-Bait | 0.2291 | 0.02204 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | ARP9 | arp9-1, rdh54-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1806 | 0.02093 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | AVT6 | avt6-Δ, rdh54-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.2621 | 0.001077 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | AVT7 | avt7-Δ, rdh54-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1361 | 0.001758 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | BCS1 | rdh54-Δ, bcs1-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1418 | 6.803E-86 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | BFA1 | bfa1-Δ, rdh54-Δ | Positive Genetic | high-throughput | Hit-Bait | 0.2479 | 0.001648 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | BRL1 | brl1-C371R, rdh54-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1323 | 2.581E-10 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | CKA1 | cka1-Δ, rdh54-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.2144 | 0.02102 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | RDH54 | COX5A | rdh54-Δ, cox5a-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.2606 | 8.056E-17 | Costanzo M, et al. (2016) PMID:27708008 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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