Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
10 entries for 8 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| IML1 | autophagy: decreased | classical genetics | null Allele: iml1-Δ | Other | Media: nitrogen starvation Details: autophagic induction and flux are decreased; monitored by the maturation and localization of autophagy marker GFP-Atg8 | Algret R, et al. (2014) PMID:25073740 | |
| IML1 | autophagy: decreased | classical genetics | null Allele: iml1-Δ | S288C | Media: nitrogen starvation Details: defective nitrogen-starvation-induced autophagy, assayed using an ALP-based assay to assess delivery of Pho8Delta60 to the vacuole | Kira S, et al. (2014) PMID:25046117 | |
| IML1 | filamentous growth: increased | systematic mutation set | null Allele: iml1-Δ | Sigma1278b | Details: greatly increased | Jin R, et al. (2008) PMID:17989363 | |
| IML1 | growth in exponential phase: decreased rate | classical genetics | null Allele: iml1-Δ | CEN.PK | Temperature: elevated temperature, 42 °C Details: significant reduction in growth rate at high temperature relative to wt | Sornlek W, et al. (2024) PMID:39230763 | |
| IML1 | oxidative stress resistance: decreased | classical genetics | null Allele: iml1-Δ | S288C | 0.75 mM hydrogen peroxide | Details: increased sensitivity to H2O2-induced oxidative stress, similar to the GTP-restricted allele of GTPase, gtr1-Q65L | Sekiguchi T, et al. (2022) PMID:35158208 |
| IML1 | protein/peptide accumulation: increased Reporter: Npr3p-GFP | classical genetics | null Allele: iml1-Δ | Other | sirolimus | Details: Npr3p is stabilized in cells treated with rapamycin | Algret R, et al. (2014) PMID:25073740 |
| IML1 | protein/peptide distribution: abnormal Reporter: Tor1p-GFP | classical genetics | null Allele: iml1-Δ | Other | Media: nitrogen starvation Details: Tor1p becomes dispersed in cytoplasmic foci after 20 hrs of nitrogen starvation, rather than remain in the vacuolar membrane | Algret R, et al. (2014) PMID:25073740 | |
| IML1 | protein/peptide modification: increased Reporter: Sch9p-Ha5 | classical genetics | null Allele: iml1-Δ | S288C | Details: elevated phosphorylation of TORC1 target Sch9p at residue T737, indicative of increased TORC1 activity | Panchaud N, et al. (2013) PMID:23716719 | |
| IML1 | protein/peptide modification: increased Reporter: Sch9p-Ha5 | classical genetics | null Allele: iml1-Δ | S288C | Media: leucine starvation Details: increased phosphorylation of TORC1 target Sch9p at residue T737, indicative of decreased sensitivity of TORC1 to leucine starvation | Panchaud N, et al. (2013) PMID:23716719 | |
| IML1 | vacuolar morphology: abnormal | classical genetics | null Allele: iml1-Δ | Other | Media: nitrogen starvation Details: significant vacuolar fragmentation; vacuolar fusion is inhibited | Algret R, et al. (2014) PMID:25073740 |
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
195 entries for 189 genesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Interactor | Interactor | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | ACE2 | iml1-Δ, ace2-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.2502 | 0.0004101 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | AIM36 | iml1-Δ, aim36-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.335 | 0.0 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | ALD6 | iml1-Δ, ald6-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.244 | 1.421E-11 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | ARP9 | iml1-Δ, arp9-1 | Negative Genetic | high-throughput | Bait-Hit | -0.1453 | 0.03456 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | ATP10 | iml1-Δ, atp10-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.2303 | 0.003166 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | BET5 | iml1-Δ, bet5-5001 | Negative Genetic | high-throughput | Bait-Hit | -0.1333 | 0.0001433 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | BOS1 | iml1-Δ, bos1-1 | Positive Genetic | high-throughput | Bait-Hit | 0.1603 | 0.009215 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | BTS1 | iml1-Δ, bts1-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1763 | 0.01525 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | COQ11 | iml1-Δ, coq11-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.165 | 0.0343 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | IML1 | CPR6 | iml1-Δ, cpr6-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1903 | 0.001292 | Costanzo M, et al. (2016) PMID:27708008 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap | YeastRC Two-Hybrid