Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
12 entries for 10 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| SHH4 | chronological lifespan: increased | systematic mutation set | null Allele: shh4-Δ | S288C | Campos SE, et al. (2018) PMID:29575540 | ||
| SHH4 | competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: shh4-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.01 | Breslow DK, et al. (2008) PMID:18622397 | |
| SHH4 | competitive fitness: increased | systematic mutation set | null Allele: shh4-Δ | S288C | Media: rich medium (YPD) w/6% ethanol, ETH | Qian W, et al. (2012) PMID:23103169 | |
| SHH4 | haploproficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: shh4-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: 0.0082 | Pir P, et al. (2012) PMID:22244311 | |
| SHH4 | innate thermotolerance: decreased | homozygous diploid, systematic mutation set | null Allele: shh4-Δ | S288C | Phase: exponential phase Treatment: heat shock, 50 °C Details: sensitivity scale of -1 (least) to -4 (most) sensitive: -2 | Jarolim S, et al. (2013) PMID:24142923 | |
| SHH4 | resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: shh4-Δ | S288C | 200 μg/mL desipramine | Lum PY, et al. (2004) PMID:14718172 | |
| SHH4 | resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: shh4-Δ | S288C | 3 mg/mL histamine | Lum PY, et al. (2004) PMID:14718172 | |
| SHH4 | resistance to chemicals: increased | systematic mutation set | null Allele: shh4-Δ | S288C | 140 mM acetic acid | Ding J, et al. (2013) PMID:23828602 | |
| SHH4 | starvation resistance: decreased | heterozygous diploid, competitive growth pooled mutant strains were subjected to low nutrient stress, then dead cells were separated and their mutations identified | null Allele: shh4-Δ | S288C | Davey HM, et al. (2012) PMID:22356628 | ||
| SHH4 | toxin resistance: increased | systematic mutation set | null Allele: shh4-Δ | S288C | Treatment: Aβ42 Details: increased resistance to the toxicity of Aβ42, a 42 AA aggregate prone proteolytic product of the human amyloid precursor protein (APP) | Chen X, et al. (2020) PMID:32054832 |
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
|---|
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
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