Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
7 entries for 2 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| SEC61 | cold sensitivity: increased | classical genetics | conditional Allele: sec61–32 C150Y | Other | Temperature: reduced temperature, 17 °C Details: strong Cs growth defect on rich and minimal medium | Pilon M, et al. (1998) PMID:9843581 | |
| SEC61 | protein transport: decreased Reporter: CPY | classical genetics | conditional Allele: sec61–32 C150Y | Other | Temperature: permissive temperature, 30 °C Details: ER translocation defect; accumulation of the CPY signal sequence containing pre-processed form (preproCPY), compared to wt cells that contain translocated and glycosylated (P1 and P2) forms as well as the mature vacuolar form (mCPY); complete block at reduced temperature | Pilon M, et al. (1997) PMID:9303298 | |
| SEC61 | protein transport: decreased Reporter: CPY | classical genetics | conditional Allele: sec61–32 C150Y | Other | Temperature: permissive temperature, 30 °C Details: ER translocation defect; accumulation of signal sequence containing pre-processed form (preproCPY), compared to wt cells where translocated (proCPY), glycosylated (P1, P2) and the mature vacuolar form (mCPY) are found | Pilon M, et al. (1998) PMID:9843581 | |
| SEC61 | protein transport: decreased Reporter: DPAPB dipeptidyl aminopeptidase B | classical genetics | conditional Allele: sec61–32 C150Y | Other | Temperature: permissive temperature, 30 °C Details: ER translocation defect; a fraction of DPAPB accumulates as an unglycosylated cytoplasmic precursor compared to the ER core glycosylated mature form seen in wt cells | Pilon M, et al. (1998) PMID:9843581 | |
| SEC61 | protein transport: decreased Reporter: Kar2p | classical genetics | conditional Allele: sec61–32 C150Y | Other | Temperature: permissive temperature, 30 °C Details: ER translocation defect; a fraction of Kar2p accumulates as a cytoplasmic precursor compared to the mature ER form present in wt cells | Pilon M, et al. (1998) PMID:9843581 | |
| SEC61 | protein transport: decreased Reporter: α-factor | classical genetics | conditional Allele: sec61–32 C150Y | Other | Temperature: permissive temperature, 30 °C Details: ER translocation defect; accumulates unprocessed prepro-alpha-factor (ppαf), the cytoplasmic precursor form of α-factor; accumulation more pronounced at reduced temperature | Pilon M, et al. (1997) PMID:9303298 | |
| SEC61 | protein transport: decreased Reporter: α-factor | classical genetics | conditional Allele: sec61–32 C150Y | Other | Temperature: permissive temperature, 30 °C Details: ER translocation defect; accumulates unprocessed prepro-α-factor, the cytoplasmic precursor form of α-factor | Pilon M, et al. (1998) PMID:9843581 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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