Phenotype Help

SHH4 / YLR164W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

12 entries for 10 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chronological lifespan: increased
systematic mutation set null
Allele: shh4-Δ
S288CCampos SE, et al. (2018) PMID:29575540
competitive fitness: increased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: shh4-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 1.01
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: increased
systematic mutation setnull
Allele: shh4-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
haploproficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: shh4-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: 0.0082
Pir P, et al. (2012) PMID:22244311
innate thermotolerance: decreased
homozygous diploid, systematic mutation setnull
Allele: shh4-Δ
S288CPhase: exponential phase
Treatment: heat shock, 50 °C
Details: sensitivity scale of -1 (least) to -4 (most) sensitive: -2
Jarolim S, et al. (2013) PMID:24142923
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: shh4-Δ
S288C200 μg/mL desipramineLum PY, et al. (2004) PMID:14718172
resistance to chemicals: decreased
heterozygous diploid, systematic mutation set null
Allele: shh4-Δ
S288C3 mg/mL histamineLum PY, et al. (2004) PMID:14718172
resistance to chemicals: increased
systematic mutation setnull
Allele: shh4-Δ
S288C140 mM acetic acidDing J, et al. (2013) PMID:23828602
starvation resistance: decreased
heterozygous diploid, competitive growth

pooled mutant strains were subjected to low nutrient stress, then dead cells were separated and their mutations identified

null
Allele: shh4-Δ
S288CDavey HM, et al. (2012) PMID:22356628
toxin resistance: increased
systematic mutation set null
Allele: shh4-Δ
S288CTreatment: Aβ42
Details: increased resistance to the toxicity of Aβ42, a 42 AA aggregate prone proteolytic product of the human amyloid precursor protein (APP)
Chen X, et al. (2020) PMID:32054832
Showing 1 to 10 of 12 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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